| http://purl.uniprot.org/citations/11741938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741938 | http://www.w3.org/2000/01/rdf-schema#comment | "To elucidate the mechanism by which isoforms of CCAAT/enhancer-binding proteins regulate cyclooxygenase-2 expression, we determined by a novel technique binding of six isoforms of this transactivator to two sequence-specific CCAAT/enhancer-binding protein (-132/-125) and cyclic AMP (-59/-53) regulatory elements in human foreskin fibroblasts treated with phorbol 12-myristate 13-acetate for 4 h. The delta isoform bound to these two elements at basal state, which was displaced by full-length as well as two truncated beta isoforms, a 41-kDa liver-enriched activating protein and a 16-kDa liver-enriched inhibitory protein, after phorbol ester stimulation. Kinetic analysis shows time-dependent changes in beta and delta binding that were concordant with time-dependent increase in cyclooxygenase-2 induction. Overexpression of the 16-kDa beta isoform blocked the promoter activity and protein level induced by phorbol ester. Paradoxically, it increased binding of beta isoforms to the sequence-specific promoter DNA but suppressed cyclooxygenase-2 promoter activation by p300 cotransfection. These findings provide new insight into the regulation of cyclooxygenase-2 promoter by an interplay between two opposite beta isoforms and p300 co-activator."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108075200"xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108075200"xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Deng W.G."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Deng W.G."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Saunders M.A."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Saunders M.A."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Wu K.K."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Wu K.K."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Yeh H."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/author | "Yeh H."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/pages | "6923-6928"xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/pages | "6923-6928"xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/title | "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/title | "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11741938 | http://purl.uniprot.org/core/volume | "277"xsd:string |