| http://purl.uniprot.org/citations/11741956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741956 | http://www.w3.org/2000/01/rdf-schema#comment | "Lck is a member of the Src family of protein-tyrosine kinases and is essential for T cell development and function. Lck is localized to the inner surface of the plasma membrane and partitions into lipid rafts via dual acylation on its N terminus. We have tested the role of Lck binding domains in regulating Lck localization to lipid rafts. A form of Lck containing a point mutation inactivating the SH3 domain (W97ALck) was preferentially localized to lipid rafts compared with wild type or SH2 domain-inactive (R154K) Lck when expressed in Lck-deficient J.CaM1 cells. W97ALck incorporated more of the radioiodinated version of palmitic acid, 16-[(125)I]iodohexadecanoic acid. Overexpression of c-Cbl, a ligand of the Lck SH3 domain, depleted Lck from lipid rafts in Jurkat cells. Additionally, Lck localization to lipid rafts was enhanced in c-Cbl-deficient T cells. The association of Lck with c-Cbl in vivo required a functional SH3 domain. These results suggest a model whereby the SH3 domain negatively regulates basal localization of Lck to lipid rafts via association with c-Cbl."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110002200"xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/author | "Magee A.I."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/author | "Harrison M.L."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/author | "Geahlen R.L."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/author | "Hawash I.Y."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/author | "Kesavan K.P."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/pages | "5683-5691"xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/title | "The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl."xsd:string |
| http://purl.uniprot.org/citations/11741956 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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