| http://purl.uniprot.org/citations/11742080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742080 | http://www.w3.org/2000/01/rdf-schema#comment | "IscR (iron-sulfur cluster regulator) is encoded by an ORF located immediately upstream of genes coding for the Escherichia coli Fe-S cluster assembly proteins, IscS, IscU, and IscA. IscR shares amino acid similarity with MarA, a member of the MarA/SoxS/Rob family of transcription factors. In this study, we found that IscR functions as a repressor of the iscRSUA operon, because strains deleted for iscR have increased expression of this operon. In addition, in vitro transcription reactions established a direct role for IscR in repression of the iscR promoter. Analysis of IscR by electron paramagnetic resonance showed that the anaerobically isolated protein contains a [2Fe-2S](1+) cluster. The Fe-S cluster appears to be important for IscR function, because repression of iscR expression is significantly reduced in strains containing null mutations of the Fe-S cluster assembly genes iscS or hscA. The finding that IscR activity is decreased in strain backgrounds in which Fe-S cluster assembly is impaired suggests that this protein may be part of a novel autoregulatory mechanism that senses the Fe-S cluster assembly status of cells."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.251550898"xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.251550898"xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Patschkowski T."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Patschkowski T."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Ruzicka F.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Ruzicka F.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Beinert H."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Beinert H."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Kiley P.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Kiley P.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Schwartz C.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Schwartz C.J."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Giel J.L."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Giel J.L."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Luther C."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/author | "Luther C."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/pages | "14895-14900"xsd:string |
| http://purl.uniprot.org/citations/11742080 | http://purl.uniprot.org/core/pages | "14895-14900"xsd:string |