| http://purl.uniprot.org/citations/11742401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742401 | http://www.w3.org/2000/01/rdf-schema#comment | "Microbial infection activates two distinct intracellular signalling cascades in the immune-responsive fat body of Drosophila. Gram-positive bacteria and fungi predominantly induce the Toll signalling pathway, whereas Gram-negative bacteria activate the Imd pathway. Loss-of-function mutants in either pathway reduce the resistance to corresponding infections. Genetic screens have identified a range of genes involved in these intracellular signalling cascades, but how they are activated by microbial infection is largely unknown. Activation of the transmembrane receptor Toll requires a proteolytically cleaved form of an extracellular cytokine-like polypeptide, Spätzle, suggesting that Toll does not itself function as a bona fide recognition receptor of microbial patterns. This is in apparent contrast with the mammalian Toll-like receptors and raises the question of which host molecules actually recognize microbial patterns to activate Toll through Spätzle. Here we present a mutation that blocks Toll activation by Gram-positive bacteria and significantly decreases resistance to this type of infection. The mutation semmelweis (seml) inactivates the gene encoding a peptidoglycan recognition protein (PGRP-SA). Interestingly, seml does not affect Toll activation by fungal infection, indicating the existence of a distinct recognition system for fungi to activate the Toll pathway."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.org/dc/terms/identifier | "doi:10.1038/414756a"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.org/dc/terms/identifier | "doi:10.1038/414756a"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Hoffmann J.A."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Hoffmann J.A."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Reichhart J.-M."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Reichhart J.-M."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Michel T."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Michel T."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Royet J."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/author | "Royet J."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/pages | "756-759"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/pages | "756-759"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/title | "Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/title | "Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein."xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/volume | "414"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://purl.uniprot.org/core/volume | "414"xsd:string |
| http://purl.uniprot.org/citations/11742401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11742401 |
| http://purl.uniprot.org/citations/11742401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11742401 |