| http://purl.uniprot.org/citations/11742996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11742996 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, histone acetyltransferase CBP-1 counteracts the repressive activity of the histone deacetylase HDA-1 to allow endoderm differentiation, which is specified by the E cell. In the sister MS cell, the endoderm fate is prevented by the action of an HMG box-containing protein, POP-1, through an unknown mechanism. In this study, we show that CBP-1, HDA-1 and POP-1 converge on end-1, an initial endoderm-determining gene. In the E lineage, an essential function of CBP-1 appears to be the activation of end-1 transcription. We further identify a molecular mechanism for the endoderm-suppressive effect of POP-1 in the MS lineage by demonstrating that POP-1 functions as a transcriptional repressor that inhibits inappropriate end-1 transcription. We provide evidence that POP-1 represses transcription via the recruitment of HDA-1 and UNC-37, the C.elegans homolog of the co-repressor Groucho. These findings demonstrate the importance of the interplay between acetyltransferases and deacetylases in the regulation of a critical cell fate-determining gene during development. Furthermore, they identify a strategy by which concerted actions of histone deacetylases and other co-repressors ensure maximal repression of inappropriate cell type-specific gene transcription."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.24.7197"xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.24.7197"xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Wen G."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Wen G."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Gay F."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Gay F."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Calvo D."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Calvo D."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Rothman J."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Rothman J."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Sui G."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Sui G."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Dufourcq P."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Dufourcq P."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Luke M.P.-S."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Luke M.P.-S."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Maduro M."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Maduro M."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Victor M."xsd:string |
| http://purl.uniprot.org/citations/11742996 | http://purl.uniprot.org/core/author | "Victor M."xsd:string |