| http://purl.uniprot.org/citations/11746825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11746825 | http://www.w3.org/2000/01/rdf-schema#comment | "Connexin 43 (Cx43), a structural component of gap junctions, is believed to function as a tumor suppressor gene. Previously, we showed that expression of Cx43 suppresses cell proliferation and tumorigenicity of human glioblastoma cells [Huang et al., Cancer Res 58:5089-5096, 1998] and enhances apoptosis in response to chemotherapeutic agents [Huang et al., Int J Cancer 92:130-138, 2001]. In the present study, we demonstrated that expression of Cx43 in human glioblastoma cells potentiated an apoptotic program under low-serum conditions. The Cx43-mediated effect was coupled with a decreased expression of the specific apoptosis-inhibitor bcl-2. Overexpression of bcl-2 in Cx43-transfected cells conferred resistance to apoptosis induced under low-serum conditions, suggesting that the Cx43-mediated apoptosis under low-serum conditions is regulated, in part, through the downregulation of bcl-2 expression. Furthermore, application of the phosphatidylinositol-3'-OH kinase inhibitor LY294002 specifically induced apoptosis in Cx43-transfected cells. Our results demonstrate a new role of Cx43 in the mediation of apoptosis under low serum conditions."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.1072"xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Huang R."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Liu Y.G."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Huang R.P."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/author | "Boynton A."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/pages | "128-138"xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/title | "Enhanced apoptosis under low serum conditions in human glioblastoma cells by connexin 43 (Cx43)."xsd:string |
| http://purl.uniprot.org/citations/11746825 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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