| http://purl.uniprot.org/citations/11748161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11748161 | http://www.w3.org/2000/01/rdf-schema#comment | "Trypanosoma cruzi is a protozoan parasite that chronically infects many mammalian species and in humans causes Chagas' disease, a chronic inflammatory disease. The parasite expresses glycophosphoinositol (GPI), which potently stimulates interleukin 12 (IL-12) production. During T. cruzi infection IL-12, and possibly GPI, might stimulate NK T cells to affect the protective and chronic inflammatory responses. Here we report that during T. cruzi infection CD1d-restricted NK T cells are stimulated as NK T-cell-deficient mice have greater parasitemia. Furthermore, during T. cruzi infection the percentages of NK T cells in the liver and spleen become decreased for prolonged periods of time, and in vitro stimulation of NK T cells derived from livers of chronically infected mice, compared to uninfected mice, results in increased gamma interferon and IL-4 secretion. Moreover, in NK T-cell-deficient mice the chronic-phase antibody response to a GPI-modified surface protein is decreased. These results indicate that, during the acute infection, NK T cells limit parasitemia and that, during the chronic phase, NK T cells augment the antibody response. Thus, during T. cruzi infection the quality of an individual's NK T-cell response can affect the level of parasitemia and parasite tissue burden, the intensity of the chronic inflammatory responses, and possibly the outcome of Chagas' disease."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.70.1.36-48.2002"xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Nakayama T."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Smith S."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Duthie M.S."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Kahn S.J."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/author | "Wleklinski-Lee M."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/pages | "36-48"xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/title | "During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein."xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/11748161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11748161 |
| http://purl.uniprot.org/citations/11748161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11748161 |
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| http://purl.uniprot.org/uniprot/#_E9Q395-mappedCitation-11748161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11748161 |
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| http://purl.uniprot.org/uniprot/B9VQY2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11748161 |
| http://purl.uniprot.org/uniprot/E9Q395 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11748161 |
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