| http://purl.uniprot.org/citations/11748204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11748204 | http://www.w3.org/2000/01/rdf-schema#comment | "Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis. Congenic pairs of wild-type and toll-like receptor 4 (tlr4)- or major histocompatibility complex class II (MHC-II)-deficient mice were used for these studies. Wild-type mice cleared the infection within 2 weeks, and the response included macrophage activation and the synthesis of E. chaffeensis-specific Th1-type immunoglobulin G response. The absence of a functional tlr4 gene depressed nitric oxide and interleukin 6 secretion by macrophages and resulted in short-term persistent infections for > or =30 days. In the absence of MHC-II alleles, E. chaffeensis infections persisted throughout the entire 3-month evaluation period. Together, these data suggest that macrophage activation and cell-mediated immunity, orchestrated by CD4(+) T cells, are critical for conferring resistance to E. chaffeensis."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.70.1.380-388.2002"xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Ganta R.R."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Cheng C."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Chapes S.K."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Wilkerson M.J."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Chapes S.K.'"xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/author | "Rokey A.M."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/pages | "380-388"xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/title | "Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes."xsd:string |
| http://purl.uniprot.org/citations/11748204 | http://purl.uniprot.org/core/volume | "70"xsd:string |
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