| http://purl.uniprot.org/citations/11751578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11751578 | http://www.w3.org/2000/01/rdf-schema#comment | "The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion. We have determined the three-dimensional crystal structure of TcMIP at 1.7 A resolution. The monomeric protein displays a peptidyl-prolyl cis-trans isomerase (PPIase) core, encompassing the characteristic rotamase hydrophobic active site, thus explaining the strong inhibition of TcMIP by the immunosuppressant FK506 and related drugs. In TcMIP, the twisted beta-sheet of the core is extended by an extra beta-strand, preceded by a long, exposed N-terminal alpha-helix, which might be a target recognition element. An invasion assay shows that the MIP protein from Legionella pneumophila (LpMIP), which has an equivalent N-terminal alpha-helix, can substitute for TcMIP. An additional exposed alpha-helix, this one unique to TcMIP, is located in the C-terminus of the protein. The high-resolution structure reported here opens the possibility for the design of new inhibitory drugs that might be useful for the clinical treatment of American trypanosomiasis."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kvf009"xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Coll M."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Gonzalez A."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Gomis-Ruth F.X."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Macedo-Ribeiro S."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Vega M.C."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Pereira P.J."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Fernandez-Carazo R."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/author | "Gonzalez-Rey E."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/pages | "88-94"xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/title | "Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix."xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/11751578 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11751578 |
| http://purl.uniprot.org/citations/11751578 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11751578 |
| http://purl.uniprot.org/uniprot/#_Q09734-mappedCitation-11751578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11751578 |
| http://purl.uniprot.org/uniprot/Q09734 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11751578 |