| http://purl.uniprot.org/citations/11751629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11751629 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosomal double-strand breaks (DSBs) in mammalian cells are repaired by either homology-directed repair (HDR), using a homologous sequence as a repair template, or nonhomologous end-joining (NHEJ), which often involves sequence alterations at the DSB site. To characterize the interrelationship of these two pathways, we analyzed HDR of a DSB in cells deficient for NHEJ components. We find that the HDR frequency is enhanced in Ku70(-/-), XRCC4(-/-), and DNA-PKcs(-/-) cells, with the increase being particularly striking in Ku70(-/-) cells. Neither sister-chromatid exchange nor gene-targeting frequencies show a dependence on these NHEJ proteins. A Ku-modulated two-ended versus one-ended chromosome break model is presented to explain these results."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.946401"xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/author | "Ellis N."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/author | "Jasin M."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/author | "Pierce A.J."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/pages | "3237-3242"xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/title | "Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/11751629 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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