| http://purl.uniprot.org/citations/11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11752574 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1066707"xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/author | "Rogers M.B."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/author | "Fuller M.T."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/author | "Schulz C."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/author | "Jones D.L."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/author | "Kiger A.A."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/pages | "2542-2545"xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/title | "Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue."xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/11752574 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11752574 |
| http://purl.uniprot.org/citations/11752574 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11752574 |
| http://purl.uniprot.org/uniprot/Q24592#attribution-F042D2B1F59D89EC503C59ED9951F2D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/Q24151#attribution-F042D2B1F59D89EC503C59ED9951F2D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/O96525#attribution-F042D2B1F59D89EC503C59ED9951F2D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_P15278-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KH10-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGE1-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGI7-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |
| http://purl.uniprot.org/uniprot/#_A8DZ14-mappedCitation-11752574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11752574 |