| http://purl.uniprot.org/citations/11752579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11752579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11752579 | http://www.w3.org/2000/01/rdf-schema#comment | "Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1066326"xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1066326"xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Martignetti J.A."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Martignetti J.A."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Eng F.J."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Eng F.J."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Heath K.E."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Heath K.E."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Glucksman M.J."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Glucksman M.J."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Narla G."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Narla G."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Chan A.M."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Chan A.M."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Friedman S.L."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Friedman S.L."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Kimmelman A.C."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Kimmelman A.C."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Ferrari A.C."xsd:string |
| http://purl.uniprot.org/citations/11752579 | http://purl.uniprot.org/core/author | "Ferrari A.C."xsd:string |