| http://purl.uniprot.org/citations/11753647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11753647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11753647 | http://www.w3.org/2000/01/rdf-schema#comment | "Human ovarian cancer cells and tissues were examined for the presence or absence of a 42-bp splicing variant of ERCC1 gene, and for a possible functional role of this 42-bp sequence. This specific sequence exists in exon I, the 5'-UTR of the gene. Loss of this 42-bp sequence was associated with increased ERCC1 mRNA expression, in an assessment of 121 ovarian cancer specimens (p2<10(-6)). In cells in tissue culture, the absence of the 42-bp segment was associated with a twofold increased ability to drive transcription in a Luciferase reporter system. Protein can be demonstrated in ovarian cancer cells based on EMSA analysis. Computer analysis shows that this 42-bp sequence contains several binding sites, including a core-binding domain for protein RFX1, transcriptional repressor. These preliminary results lay the groundwork in determination of potential roles for a negative regulatory element in NER repair pathway."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204977"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204977"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Yu J.J."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Yu J.J."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Thornton K."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Thornton K."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Reed E."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Reed E."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Kotz H."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/author | "Kotz H."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/pages | "7694-7698"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/pages | "7694-7698"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/title | "An ERCC1 splicing variant involving the 5'-UTR of the mRNA may have a transcriptional modulatory function."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/title | "An ERCC1 splicing variant involving the 5'-UTR of the mRNA may have a transcriptional modulatory function."xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11753647 | http://purl.uniprot.org/core/volume | "20"xsd:string |