| http://purl.uniprot.org/citations/11754004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11754004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11754004 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported the cloning of two triggering receptors expressed by myeloid cells (TREM), TREM-2a and TREM-2b, which are highly homologous to each other. These receptors associate with DAP12, and ligation of TREM-2 on the surface of macrophages leads to the release of nitric oxide. Using the immunoglobulin (Ig) domain of TREM-2 to screen a mouse EST database we have isolated a novel receptor, derived from a WEHI-3 macrophage library, which shows homology to TREM-2 (20%). The DNA sequence of this receptor has been submitted to Genbank with the name TREM-3. The predicted amino acid sequence contains a single Ig domain and a transmembrane lysine residue. We found transcripts for TREM-3 in two macrophage cell lines (RAW264.7 and MT2) but not in P388D1 macrophage cells. TREM-3 transcripts could also be detected at low levels in T cell lines, but were not detectable in NK, B cell, or mast cell lines. Furthermore, in macrophage cells, transcripts for TREM-3 were up-regulated by LPS, but were down-regulated by IFN-gamma. Like TREM-1 and TREM-2, TREM-3 signals through DAP12, and when TREM-3 is transfected into an NK cell line it mediates redirected lysis. Thus, TREM-3 functions as an activating receptor. Analysis of the mouse genome reveals that the gene for TREM-3 lies adjacent to the gene for TREM-1 and in close proximity to a number of other single Ig domain receptors, including TREM-2. Thus, TREM-3 is a novel member of a family of immunoglobulin receptors that form an innate immune gene complex on chromosome 17."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200201)32:1<59::aid-immu59>3.0.co;2-u"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200201)32:1<59::aid-immu59>3.0.co;2-u"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Chung D.H."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Chung D.H."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Seaman W.E."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/author | "Seaman W.E."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/pages | "59-66"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/pages | "59-66"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/title | "Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/title | "Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17."xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/11754004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11754004 |
| http://purl.uniprot.org/citations/11754004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11754004 |
| http://purl.uniprot.org/citations/11754004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11754004 |
| http://purl.uniprot.org/citations/11754004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11754004 |