| http://purl.uniprot.org/citations/11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11754824 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8(+) T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(01)00252-7"xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Miller J.D."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Altman J.D."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Kavathas P."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Daniels M.A."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Moser J.M."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Jameson S.C."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Lukacher A.E."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Hogquist K.A."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/author | "Devine L."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/pages | "1051-1061"xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/title | "CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation."xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/11754824 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11754824 |
| http://purl.uniprot.org/citations/11754824 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11754824 |
| http://purl.uniprot.org/uniprot/#_P10300-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |
| http://purl.uniprot.org/uniprot/#_Q8BH77-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |
| http://purl.uniprot.org/uniprot/#_Q8CAX3-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |
| http://purl.uniprot.org/uniprot/#_Q3TEK8-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |
| http://purl.uniprot.org/uniprot/#_Q3TR81-mappedCitation-11754824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11754824 |