| http://purl.uniprot.org/citations/11756244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11756244 | http://www.w3.org/2000/01/rdf-schema#comment | "Werner syndrome (WS) is a rare autosomal recessive disorder characterized by genomic instability and the premature onset of a number of age-related diseases, including cancers. Accumulating evidence indicates that the WS gene product is involved in resolving aberrant DNA structures that may arise during the process of DNA replication and/or transcription. To estimate the frequency of DNA deletions directly in the skin of mouse embryos, mice with a deletion of part of the murine WRN helicase domain were created. These mutant mice were then crossed to the pink-eyed unstable animals, which have a 70 kb internal duplication at the pink-eyed dilution (p) gene. This report indicates that the frequency of deletion of the duplicated sequence at the p locus is elevated in mice with a mutation in the WRN allele when compared with wild-type mice. In addition, the inhibitor of topoisomerase I camptothecin also increases the frequency of deletion at the p locus. This frequency is even more elevated in WRN mutant mice treated with camptothecin. In contrast, while the inhibition of poly(ADP-ribose) polymerase (PARP) activity by 3-aminobenzamide increases the frequency of DNA deletion, mutant WRN mice are not significantly more sensitive to the inhibition of PARP activity than wild-type animals."xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/23.1.213"xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/author | "Lebel M."xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/pages | "213-216"xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/title | "Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue."xsd:string |
| http://purl.uniprot.org/citations/11756244 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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