| http://purl.uniprot.org/citations/11756406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11756406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11756406 | http://www.w3.org/2000/01/rdf-schema#comment | "There are only three human isoforms of the small GTPase Rac, which together regulate a variety of cellular processes, including those related to actin cytoskeletal reorganization. A role for Rac3 in integrin-mediated adhesion and spreading has not been defined. We here report that CIB, a protein that binds to the alpha(IIb)beta(3) fibrinogen receptor, interacts exclusively with activated (V12) Rac3 but not Rac1 or Rac2. Binding of V12Rac3 to CIB was mediated by the C-terminal end of Rac3 and by Rac3 membrane localization. Adhesion of cells on fibrinogen was accompanied by a specific increase in the levels of Rac3 but not Rac1 or Rac2 in the Triton-insoluble fraction of the cell. Also, CIB co-localized with active Rac3 to the periphery of cells adhering to fibrinogen. Expression of V12Rac3 and CIB stimulated alpha(IIb)beta(3)-mediated adhesion and spreading on fibrinogen. Moreover, adhesion through alpha(IIb)beta(3) caused a marked increase in the levels of endogenous GTP-bound Rac3 but not Rac1. These combined results strongly implicate Rac3 and CIB in integrin-associated cytoskeletal reorganization during alpha(IIb)beta(3)-mediated adhesion."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m105363200"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m105363200"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Groffen J."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Groffen J."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Heisterkamp N."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Heisterkamp N."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Kaartinen V."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Kaartinen V."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Haataja L."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/author | "Haataja L."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/pages | "8321-8328"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/pages | "8321-8328"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/title | "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/title | "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading."xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11756406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11756406 |
| http://purl.uniprot.org/citations/11756406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11756406 |