| http://purl.uniprot.org/citations/11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11764295 | http://www.w3.org/2000/01/rdf-schema#comment | "Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the MITF gene cause auditory-pigmentary syndromes. MITF consists of at least five isoforms, MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, differing at their N-termini and expression patterns. Here we show a remarkable similarity between the N-terminal domain of MITF-A and cytoplasmic retinoic acid-binding proteins. To date, four isoform-specific first exons have been identified in the MITF gene: exons 1A, 1H, 1B, and 1M in the 5' to 3' direction, each of which encodes the unique N-terminus of a given isoform. The 5'-flanking regions of these isoform-specific exons are termed A, H, B, and M promoters, respectively. Among these promoters, the M promoter has received particular attention, because it is functional only in melanocyte-lineage cells and is upregulated by Wnt signaling via the functional LEF-1-binding site. Moreover, the M promoter is upregulated by other transcription factors, PAX3, SOX10, and CREB. The activity and degradation of MITF-M are regulated by extracellular signals via protein phosphorylation, such as c-Kit signaling. Together, multiple signals appear to converge on the M promoter as well as on MITF proteins, leading to the proper regulation of MITF-M in melanocytes and other MITF isoforms in many cell types."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.0022-202x.2001.00010.x"xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Yasumoto K."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Shibahara S."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/author | "Udono T."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/name | "J Investig Dermatol Symp Proc"xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/pages | "99-104"xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/title | "Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation."xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/11764295 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11764295 |
| http://purl.uniprot.org/citations/11764295 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11764295 |
| http://purl.uniprot.org/uniprot/#_A0A087WXU1-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_A0A0H3W5T2-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_A0A8F9W6H4-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_A0A0A7NWS7-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_B4DNC7-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_A8K5K3-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_Q32MU7-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |
| http://purl.uniprot.org/uniprot/#_I6L9I6-mappedCitation-11764295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11764295 |