| http://purl.uniprot.org/citations/11773626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11773626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11773626 | http://www.w3.org/2000/01/rdf-schema#comment | "Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. It was shown recently that human tyrosyl-tRNA synthetase (TyrRS) can be split into two fragments having distinct cytokine activities, thereby linking protein synthesis to cytokine signaling pathways. Tryptophanyl-tRNA synthetase (TrpRS) is a close homologue of TyrRS. A natural fragment, herein designated as mini TrpRS, was shown by others to be produced by alternative splicing. Production of this fragment is reported to be stimulated by IFN-gamma, a cytokine that also stimulates production of angiostatic factors. Mini TrpRS is shown here to be angiostatic in a mammalian cell culture system, the chicken embryo, and two independent angiogenesis assays in the mouse. The full-length enzyme is inactive in the same assays. Thus, protein synthesis may be linked to the regulation of angiogenesis by a natural fragment of TrpRS."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.012602099"xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.012602099"xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Schimmel P."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Schimmel P."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Wakasugi K."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Wakasugi K."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Cheresh D.A."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Cheresh D.A."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Otani A."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Otani A."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Friedlander M."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Friedlander M."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Ewalt K.L."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Ewalt K.L."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Hood J."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Hood J."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Slike B.M."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/author | "Slike B.M."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11773626 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |