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http://purl.uniprot.org/citations/11775126http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11775126http://www.w3.org/2000/01/rdf-schema#comment"

Background

Several studies implicate polymorphisms in the human beta-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area.

Methods

We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5' leader cistron; another C/T transition that results in a glycine/ arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln).

Results

The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population.

Conclusions

The Glyl6 allele in the beta2-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.org/dc/terms/identifier"doi:10.1016/s0895-7061(01)02213-0"xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Cox D.R."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Hebert J."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Botstein D."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Curb D."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Pratt R."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Ranade K."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Risch N."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Chen Y.D."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Olivier M."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Chiang F.T."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Olshen R."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Pesich R."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Hsuing C.A."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Hung Y.J."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/author"Shue W.H."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/name"Am J Hypertens"xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/pages"1196-1200"xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/title"The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin."xsd:string
http://purl.uniprot.org/citations/11775126http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/11775126http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11775126
http://purl.uniprot.org/citations/11775126http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11775126
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