| http://purl.uniprot.org/citations/11776402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11776402 | http://www.w3.org/2000/01/rdf-schema#comment | "Monocyte chemoattractant protein (MCP)-1 is a chemotactic cytokine for monocytes, memoryT cells and dendritic cells (DC). However, the precise role of MCP-1 in a variety of immunological responses remains unclear. In the present study, we analyzed contact hypersensitivity (CHS) using human MCP-1 transgenic mice (hMCP-1Tgm) that constitutively produce high levels of hMCP-1 in the sera. Following 2,4-dinitrofluorobenzene (DNFB) sensitization, enhancement of CHS was demonstrated in Tgm as compared with that in non-Tgm. Anti-hMCP-1 antibodies significantly inhibited the CHS in Tgm. A prominent accumulation of B7-1+I-Ad+ Langerhans' cells (LC) bearing haptens was detected in draining lymph nodes (DLN) of Tgm 24 h after DNFB or fluorescein isothiocyanate (FITC) sensitization. Similar results were obtained with BALB/c mice administrated recombinant (r) hMCP-1. Langerhans' cells (LC) in the epidermal sheets of Tgm increased in size and expressed high levels of I-Ad and B7-1 12 h after FITC application compared with those of non-Tgm. After 18 h, the number of LC in the epidermis was reduced in Tgm. It was also shown that the B7-1 expression on LC of BALB/c mice was augmented after culture with rhMCP-1. These findings demonstrate that MCP-1 not only accelerates LC migration from epidermis into the DLN after sensitization with haptens but also up-regulates the I-Ad and B7-1 expressions, which results in the enhanced T cell activation and CHS."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.org/dc/terms/identifier | "doi:10.1078/0171-2985-00057"xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Kawashima T."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Kobayashi H."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Onoe K."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Iwabuchi C."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Ato M."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Ohkawara A."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Mizumoto N."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Iwabichi K."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/author | "Shibaki A."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/pages | "477-493"xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/title | "Enhanced contact hypersensitivity in human monocyte chemoattractant protein-1 transgenic mouse."xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/11776402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11776402 |
| http://purl.uniprot.org/citations/11776402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11776402 |
| http://purl.uniprot.org/uniprot/#_J3KRT7-mappedCitation-11776402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11776402 |
| http://purl.uniprot.org/uniprot/#_P13500-mappedCitation-11776402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11776402 |
| http://purl.uniprot.org/uniprot/#_Q6UZ82-mappedCitation-11776402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11776402 |
| http://purl.uniprot.org/uniprot/#_V9GZU2-mappedCitation-11776402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11776402 |
| http://purl.uniprot.org/uniprot/V9GZU2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11776402 |