| http://purl.uniprot.org/citations/11777919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11777919 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-alpha (TNF) receptor-associated factor 2 (TRAF2) is one of the major mediators of TNF receptor superfamily transducing TNF signaling to various functional targets, including activation of NF-kappa B, JNK, and antiapoptosis. We investigated how TRAF2 mediates differentially the distinct downstream signals. We now report a novel mechanism of TRAF2-mediated signal transduction revealed by an association of TRAF2 with sphingosine kinase (SphK), a lipid kinase that is responsible for the production of sphingosine 1-phosphate. We identified a TRAF2-binding motif of SphK that mediated the interaction between TRAF2 and SphK resulting in the activation of the enzyme, which in turn is required for TRAF2-mediated activation of NF-kappa B but not JNK. In addition, by using a kinase inactive dominant-negative SphK and a mutant SphK that lacks TRAF2-binding motif we show that the interaction of TRAF2 with SphK and subsequent activation of SphK are critical for prevention of apoptosis during TNF stimulation. These findings show a role for SphK in the signal transduction by TRAF2 specifically leading to activation of NF-kappa B and antiapoptosis."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111423200"xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Xia P."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "D'Andrea R.J."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Moretti P.A."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Pitson S.M."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Vadas M.A."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Gamble J.R."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Chai F."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/author | "Albanese N."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/pages | "7996-8003"xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/title | "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling."xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11777919 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11777919 |
| http://purl.uniprot.org/citations/11777919 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11777919 |
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| http://purl.uniprot.org/uniprot/#_Q12933-mappedCitation-11777919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11777919 |
| http://purl.uniprot.org/uniprot/#_Q53ZR5-mappedCitation-11777919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11777919 |