| http://purl.uniprot.org/citations/11777953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11777953 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD4(+)CD25(+) regulatory T cells can be found in the thymus, but their need to undergo positive and negative selection has been questioned. Instead, it has been hypothesized that CD4(+)CD25(+) cells mature following TCR binding to MHC backbone, to low abundant MHC/peptide complexes, or to class II MHC loaded with peripheral autoantigens. In all these circumstances, processes that are distinct from positive and negative selection would govern the provenance of CD4(+)CD25(+) cells in the thymus. By comparing the development of CD4(+)CD25(-) and CD4(+)CD25(+) cells in mice expressing class II MHC molecules bound with one or many peptide(s), we show that the CD4(+)CD25(+) cells appear during natural selection of CD4(+) T cells. The proportion of CD4(+)CD25(+) cells in the population of CD4(+) thymocytes remains constant, and their total number reflects the complexity of selecting class II MHC/peptide complexes. Hence, thymic development of CD4(+)CD25(+) cells does not exclusively depend on the low-density, high-affinity MHC/peptide complexes or thymic presentation of peripheral self-Ags, but, rather, these cells are selected as a portion of the natural repertoire of CD4(+) T cells. Furthermore, while resistant to deletion mediated by endogenous superantigen(s), these cells were negatively selected on class II MHC/peptide complexes. We postulate that while the CD4(+)CD25(+) thymocytes are first detectable in the thymic medulla, their functional commitment occurs in the thymic cortex."xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.168.2.613"xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/author | "Ignatowicz L."xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/author | "Kraj P."xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/author | "Pacholczyk R."xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/pages | "613-620"xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/title | "Peptide specificity of thymic selection of CD4+CD25+ T cells."xsd:string |
| http://purl.uniprot.org/citations/11777953 | http://purl.uniprot.org/core/volume | "168"xsd:string |
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