| http://purl.uniprot.org/citations/11777987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11777987 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the role of HLA-DQ molecules and/or CD4(+) T cells in the pathogenesis of allergic asthma, we generated HLA-DQ6 and HLA-DQ8 transgenic mice lacking endogenous class II (Abeta(null)) and CD4 genes and challenged them intranasally with short ragweed allergenic extract (SRW). We found that DQ6/CD4(null) mice developed a strong eosinophilic infiltration into the bronchoalveolar lavage and lung tissue, while DQ8/CD4(null) mice were normal. However, neither cytokines nor eosinophil peroxidase in the bronchoalveolar lavage of DQ6/CD4(null) mice was found. In addition, the airway reactivity to methacholine was elevated moderately in DQ6/CD4(null) mice compared with the high response in DQ/CD4(+) counterparts and was only partially augmented by CD4(+) T cell transfer. The DQ6/CD4(null) mice showed Th1/Th2-type cytokines and SRW-specific Abs in the immune sera in contrast to a direct Th2 response observed in DQ6/CD4(+) mice. The proliferative response of spleen mononuclear cells and peribronchial lymph node cells demonstrated that the response to SRW in DQ6/CD4(null) mice was mediated by HLA-DQ-restricted CD4(-)CD8(-)NK1.1(-) T cells. FACS analysis of PBMC and spleen mononuclear cells demonstrated an expansion of double-negative (DN) CD4(-)CD8(-)TCRalphabeta(+) T cells in SRW-treated DQ6/CD4(null) mice. These cells produced IL-4, IL-5, IL-13, and IFN-gamma when stimulated with immobilized anti-CD3. IL-5 ELISPOT assay revealed that DN T cells were the cellular origin of IL-5 in allergen-challenged DQ6/CD4(null) mice. Our study shows a role for HLA-DQ-restricted CD4(+) and DN T cells in the allergic response."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.168.2.890"xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Iijima K."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Chapoval A.I."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "David C.S."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Smart M.K."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Andrews A.G."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Chapoval S.P."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/author | "Marietta E.V."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/pages | "890-899"xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/title | "Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene."xsd:string |
| http://purl.uniprot.org/citations/11777987 | http://purl.uniprot.org/core/volume | "168"xsd:string |
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