| http://purl.uniprot.org/citations/11779185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11779185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11779185 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural-restrictive silencer element (NRSE)/repressor element-1 (RE1) regulates neuron-specific gene expression by binding the transcriptional factor REST/NRSF which functions as a silencer in nonneuronal cells. In neuronal cells, a truncated, neuronal-specific REST/NRSF isoform, REST4, has been found but little is known about its function. To address this, we investigated the effect of REST/NRSF and REST4 on the activity-dependent activation of BDNF gene promoter I (BDNFp-I) using cultured rat cortical neurons. REST/NRSF markedly repressed the transcriptional activation of BDNFp-I, whereas the effect of REST4 was weak, depending upon the NRSE/RE1 sequence. In addition, REST4 enhanced the basal transcriptional activity of BDNFp-I. Coexpression of REST4 with REST/NRSF competitively inhibited the silencing effect of REST/NRSF on the activation of BDNFp-I. Although REST4 itself has a weak repressive effect on activation of the BDNF gene via NRSE/RE1, it can compete the silencing effect of REST/NRSF, suggesting a primary role for REST4 in preventing the neuron-specific gene from being inactivated by REST/NRSF and allowing gene activation in response to a variety of neuronal stimuli."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.6194"xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.6194"xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Mori N."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Mori N."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Tsuda M."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Tsuda M."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Tabuchi A."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Tabuchi A."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Naruse Y."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Naruse Y."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Sasagawa S."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/author | "Sasagawa S."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/pages | "415-420"xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/pages | "415-420"xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/title | "REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation."xsd:string |
| http://purl.uniprot.org/citations/11779185 | http://purl.uniprot.org/core/title | "REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation."xsd:string |