| http://purl.uniprot.org/citations/11779465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11779465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11779465 | http://www.w3.org/2000/01/rdf-schema#comment | "The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress. In addition, ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival. We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00612-2"xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00612-2"xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Kurnit D.M."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Kurnit D.M."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Kaufman R.J."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Kaufman R.J."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Ellis R.E."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Ellis R.E."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Liu C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Liu C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Morimoto R."xsd:string |
| http://purl.uniprot.org/citations/11779465 | http://purl.uniprot.org/core/author | "Morimoto R."xsd:string |