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http://purl.uniprot.org/citations/11779478http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11779478http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11779478http://www.w3.org/2000/01/rdf-schema#comment"Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia. The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(01)00576-1"xsd:string
http://purl.uniprot.org/citations/11779478http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(01)00576-1"xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Chamovitz D.A."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Chamovitz D.A."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Zipursky S.L."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Zipursky S.L."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Segal D."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Segal D."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Suh G.S.B."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Suh G.S.B."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Oron E."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Oron E."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Chouard T."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Chouard T."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Poeck B."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/author"Poeck B."xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/name"Neuron"xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/name"Neuron"xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/pages"35-46"xsd:string
http://purl.uniprot.org/citations/11779478http://purl.uniprot.org/core/pages"35-46"xsd:string