| http://purl.uniprot.org/citations/11779495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11779495 | http://www.w3.org/2000/01/rdf-schema#comment | "Although nonhomologous end-joining (NHEJ) deficiency has been shown to accelerate lymphoma formation in mice, its role in suppressing tumors in cells that do not undergo V(D)J recombination is unclear. Utilizing a tumor-prone mouse strain (ink4a/arf(-/-)), we examined the impact of haploinsufficiency of a NHEJ component, DNA ligase IV (Lig4), on murine tumorigenesis. We demonstrate that lig4 heterozygosity promotes the development of soft-tissue sarcomas that possess clonal amplifications, deletions, and translocations. That these genomic alterations are relevant in tumorigenesis is supported by the finding of frequent mdm2 amplification, a known oncogene in human sarcoma. Together, these findings support the view that loss of a single lig4 allele results in NHEJ activity being sufficiently reduced to engender chromosomal aberrations that drive non-lymphoid tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00425-7"xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Morton C.C."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Fleming J."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Chin L."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Frank K."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "DePinho R.A."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Ferguson D.O."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Castrillon D.H."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Sharpless N.E."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "O'Hagan R.C."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Alson S."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/author | "Farazi P.A."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/pages | "1187-1196"xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/title | "Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions."xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11779495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11779495 |
| http://purl.uniprot.org/citations/11779495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11779495 |
| http://purl.uniprot.org/uniprot/Q8BTF7#attribution-8BDA25978AD3C6D18CC372AAFD9E158D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11779495 |
| http://purl.uniprot.org/uniprot/#_A7LP29-mappedCitation-11779495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11779495 |