| http://purl.uniprot.org/citations/11780111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11780111 | http://www.w3.org/2000/01/rdf-schema#comment | "The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.org/dc/terms/identifier | "doi:10.1038/415045a"xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Cooper B."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Jones S."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Bradley A."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Thompson T."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Donehower L.A."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Karsenty G."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Venkatachalam S."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Brayton C."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Tyner S.D."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Ghebranious N."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Igelmann H."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/author | "Soron G."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/pages | "45-53"xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/title | "p53 mutant mice that display early ageing-associated phenotypes."xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://purl.uniprot.org/core/volume | "415"xsd:string |
| http://purl.uniprot.org/citations/11780111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11780111 |
| http://purl.uniprot.org/citations/11780111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11780111 |