| http://purl.uniprot.org/citations/11781350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11781350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11781350 | http://www.w3.org/2000/01/rdf-schema#comment | "Proper control of cell cycle progression is critical for the constant self-renewal, differentiation, and homeostasis of the hematopoietic system. Cells of all types share the common cell cycle regulators. The different expression patterns of common regulators, in a broad sense, define cell-type or lineage specificity. However, there remains the possibility of hematopoietic cell cycle regulators tailored to the demands of the hematopoietic system. Here we describe a novel protein, HTm4, which serves as a hematopoietic cell cycle regulator. Our data indicate that HTm4 is expressed in hematopoietic tissues and is tightly regulated during the differentiation of hematopoietic stem cells. It binds to cyclin-dependent kinase-associated (CDK-associated) phosphatase-CDK2 (KAP-CDK2) complexes, and the three proteins demonstrate similar patterns of cellular expression in human lymphoid tissues. HTm4 stimulates the phosphatase activity of KAP, and its C-terminal region is required for binding to KAP-CDK2 complexes and the modulation of KAP activity. Overexpression of HTm4 can cause cell cycle arrest at the G(0)/G(1) phase. Thus, HTm4 is a novel hematopoietic modulator for the G(1)-S cell cycle transition."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci14025"xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci14025"xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Beach D."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Beach D."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Shirakawa T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Shirakawa T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Cheng T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Cheng T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Ko J."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Ko J."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Sayegh M.H."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Sayegh M.H."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Scadden D.T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Scadden D.T."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Adra C.N."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Adra C.N."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Donato J.-L."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Donato J.-L."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Mao X.-Q."xsd:string |
| http://purl.uniprot.org/citations/11781350 | http://purl.uniprot.org/core/author | "Mao X.-Q."xsd:string |