| http://purl.uniprot.org/citations/11782436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782436 | http://www.w3.org/2000/01/rdf-schema#comment | "HeLa cytoplasmic extracts contain both 3'-5' and 5'-3' exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3'-5' exonucleolytic decay is the major pathway of RNA degradation following deadenylation in HeLa cytoplasmic extracts. Immunodepletion using antibodies specific for the exosomal protein PM-Scl75 demonstrated that the human exosome complex is required for efficient 3'-5' exonucleolytic decay. Furthermore, 3'-5' exonucleolytic decay was stimulated dramatically by AU-rich instability elements (AREs), implicating a role for the exosome in the regulation of mRNA turnover. Finally, PM-Scl75 protein was found to interact specifically with AREs. These data suggest that the interaction between the exosome and AREs plays a key role in regulating the efficiency of ARE-containing mRNA turnover."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.1.165"xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.1.165"xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Mukherjee D."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Mukherjee D."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Wilusz J."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Wilusz J."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "O'Connor J.P."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "O'Connor J.P."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Lutz C.S."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Lutz C.S."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Pruijn G."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/author | "Pruijn G."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/pages | "165-174"xsd:string |
| http://purl.uniprot.org/citations/11782436 | http://purl.uniprot.org/core/pages | "165-174"xsd:string |