| http://purl.uniprot.org/citations/11782446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782446 | http://www.w3.org/2000/01/rdf-schema#comment | "Direct interactions between RNA-binding proteins and snRNP particles modulate eukaryotic pre-mRNA processing patterns to control gene expression. Here, we report that the conserved U1 snRNP-interacting RNA-binding protein PSI is essential for Drosophila viability. A null PSI mutation is recessive lethal at the first-instar larval stage, and lethality is fully rescued by transgenes expressing the PSI protein. A mutant transgene that lacks the PSI-U1 snRNP-interaction domain restores viability but shows courtship behavior abnormalities and meiosis defects during spermatogenesis, resulting in a complete male sterility phenotype. Using cDNA microarrays, we have identified specific target mRNAs with altered expression profiles in these mutant males. A subset of these transcripts is also found associated with PSI in endogenous immunopurified ribonucleoprotein complexes. One specific target, the hrp40/squid transcript, shows an altered pre-mRNA splicing pattern in PSI mutant testes. We conclude that a functional association between the PSI protein and the spliceosomal U1 snRNP particle is required for normal Drosophila development and for the processing of specific PSI-interacting cellular transcripts. These results also validate the use of cDNA microarrays to characterize in vivo RNA-processing defects and alternative pre-mRNA splicing patterns."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.948602"xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/author | "Adams M.D."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/author | "Blanchette M."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/author | "Rio D.C."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/author | "Labourier E."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/author | "Feiger J.W."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/pages | "72-84"xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/title | "The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing."xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/11782446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11782446 |
| http://purl.uniprot.org/citations/11782446 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11782446 |
| http://purl.uniprot.org/uniprot/Q7JPS0#attribution-3A181C58DCAD12E236669EA7B116899B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
| http://purl.uniprot.org/uniprot/Q7JPS0#attribution-F047229BD0418E514AEADBB057345ACB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
| http://purl.uniprot.org/uniprot/A1ZAK7#attribution-3A181C58DCAD12E236669EA7B116899B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
| http://purl.uniprot.org/uniprot/A1ZAK7#attribution-F047229BD0418E514AEADBB057345ACB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
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| http://purl.uniprot.org/uniprot/O96828#attribution-3A181C58DCAD12E236669EA7B116899B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
| http://purl.uniprot.org/uniprot/O96828#attribution-F047229BD0418E514AEADBB057345ACB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782446 |
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