| http://purl.uniprot.org/citations/11782448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782448 | http://www.w3.org/2000/01/rdf-schema#comment | "The budding yeast kinetochore is composed of an inner and outer protein complex, which binds to centromere (CEN) DNA and attaches to microtubules. We performed a genetic synthetic dosage lethality screen to identify novel kinetochore proteins in a collection of chromosome transmission fidelity mutants. Our screen identified several new kinetochore-related proteins including YLR381Wp/Ctf3p, which is a member of a conserved family of centromere-binding proteins. Ctf3p interacts with Mcm22p, Mcm16p, and the outer kinetochore protein Ctf19p. We used chromatin immunoprecipitation to demonstrate that Ctf3p, Mcm22p, and Mcm16p bind to CEN DNA in a Ctf19p-dependent manner. In addition, Ctf3p, Mcm22p, and Mcm16p have a localization pattern similar to other kinetochore proteins. The fission yeast Ctf3p homolog, Mis6, is required for loading of a CENP-A centromere specific histone, Cnp1, onto centromere DNA. We find however that Ctf3p is not required for loading of the budding yeast CENP-A homolog, Cse4p, onto CEN DNA. In contrast, Ctf3p and Ctf19p fail to bind properly to the centromere in a cse4-1 mutant strain. We conclude that the requirements for CENP-A loading onto centromere DNA differ in fission versus budding yeast."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.949302"xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.949302"xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Fields S."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Fields S."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Davis T.N."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Davis T.N."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hieter P."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hieter P."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Givan S.A."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Givan S.A."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Cagney G."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Cagney G."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hailey D.W."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hailey D.W."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hyland K.M."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Hyland K.M."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Measday V."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Measday V."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Pot I."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/author | "Pot I."xsd:string |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11782448 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |