| http://purl.uniprot.org/citations/11782539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11782539 | http://www.w3.org/2000/01/rdf-schema#comment | "The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin is a potent transducer of hypertrophic stimuli. Calcineurin dephosphorylates members of the nuclear factor of activated T cell (NFAT) family of transcription factors, which results in their translocation to the nucleus and activation of calcium-dependent genes. Glycogen synthase kinase-3 (GSK-3) phosphorylates NFAT proteins and antagonizes the actions of calcineurin by stimulating NFAT nuclear export. To determine whether activated GSK-3 can act as an antagonist of hypertrophic signaling in the adult heart in vivo, we generated transgenic mice that express a constitutively active form of GSK-3 beta under control of a cardiac-specific promoter. These mice were physiologically normal under nonstressed conditions, but their ability to mount a hypertrophic response to calcineurin activation was severely impaired. Similarly, cardiac-specific expression of activated GSK-3 beta diminished hypertrophy in response to chronic beta-adrenergic stimulation and pressure overload. These findings reveal a role for GSK-3 beta as an inhibitor of hypertrophic signaling in the intact myocardium and suggest that elevation of cardiac GSK-3 beta activity may provide clinical benefit in the treatment of pathologic hypertrophy and heart failure."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.231619298"xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Hill J.A."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Frey N."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Shelton J.M."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "McKinsey T.A."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Antos C.L."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "McAnally J."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/author | "Kutschke W."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/pages | "907-912"xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/title | "Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo."xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11782539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11782539 |
| http://purl.uniprot.org/citations/11782539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11782539 |
| http://purl.uniprot.org/uniprot/Q9WV60#attribution-EA30B64DC8EBC46BD7803ED694044588 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782539 |
| http://purl.uniprot.org/uniprot/P63328#attribution-EA30B64DC8EBC46BD7803ED694044588 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11782539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR90-mappedCitation-11782539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11782539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT92-mappedCitation-11782539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11782539 |
| http://purl.uniprot.org/uniprot/#_A0A338P6P8-mappedCitation-11782539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11782539 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-11782539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11782539 |