| http://purl.uniprot.org/citations/11784094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11784094 | http://www.w3.org/2000/01/rdf-schema#comment | "The establishment of anterior-posterior polarity in the Caenorhabditis elegans embryo requires the activity of the maternally expressed par genes. We report the identification and analysis of a new par gene, par-5. We show that par-5 is required for asynchrony and asymmetry in the first embryonic cell divisions, normal pseudocleavage, normal cleavage spindle orientation at the two-cell stage, and localization of P granules and MEX-5 during the first and subsequent cell cycles. Furthermore, par-5 activity is required in the first cell cycle for the asymmetric cortical localization of PAR-1 and PAR-2 to the posterior, and PAR-3, PAR-6, and PKC-3 to the anterior. When PAR-5 is reduced by mutation or by RNA interference, these proteins spread around the cortex of the one-cell embryo and partially overlap. We have shown by sequence analysis of par-5 mutants and by RNA interference that the par-5 gene is the same as the ftt-1 gene, and encodes a 14-3-3 protein. The PAR-5 14-3-3 protein is present in gonads, oocytes, and early embryos, but is not asymmetrically distributed. Our analysis indicates that the par-5 14-3-3 gene plays a crucial role in the early events leading to polarization of the C. elegans zygote."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.2001.0489"xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Shakes D.C."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Golden A."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Morton D.G."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Dichoso D."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/author | "Nugent S."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/pages | "47-58"xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo."xsd:string |
| http://purl.uniprot.org/citations/11784094 | http://purl.uniprot.org/core/volume | "241"xsd:string |
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| http://purl.uniprot.org/citations/11784094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11784094 |
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