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| http://purl.uniprot.org/citations/11788835 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurofibromatosis type 1 (NF1) is a dominant genetic disorder characterized by multiple benign and malignant nervous system tumors, and by learning defects in 45% of children with NF1 mutations. Studies of neurofibromin, the protein encoded by NF1, have focused on its functions in tumorigenesis and regulation of Ras activity; however, Drosophila NF1 regulates both Ras and cyclic AMP (cAMP) pathways. Expression of a human NF1 transgene rescued cAMP-related phenotypes in NF1 mutant flies (small body size and G protein-stimulated adenylyl cyclase (AC) activity defects), and neuropeptide- and G protein-stimulated AC activity were lower in Nf1-/- as compared to Nf1+/-mouse brains, demonstrating that neurofibromin regulates AC activity in both mammals and flies."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn792"xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/author | "Tong J."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/author | "Bernards A."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/author | "Hannan F."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/pages | "95-96"xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/title | "Neurofibromin regulates G protein-stimulated adenylyl cyclase activity."xsd:string |
| http://purl.uniprot.org/citations/11788835 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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