| http://purl.uniprot.org/citations/11792714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11792714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11792714 | http://www.w3.org/2000/01/rdf-schema#comment | "Urea transporter UT-B has been proposed to be the major urea transporter in erythrocytes and kidney-descending vasa recta. The mouse UT-B cDNA was isolated and encodes a 384-amino acid urea-transporting glycoprotein expressed in kidney, spleen, brain, ureter, and urinary bladder. The mouse UT-B gene was analyzed, and UT-B knockout mice were generated by targeted gene deletion of exons 3-6. The survival and growth of UT-B knockout mice were not different from wild-type littermates. Urea permeability was 45-fold lower in erythrocytes from knockout mice than from those in wild-type mice. Daily urine output was 1.5-fold greater in UT-B-deficient mice (p < 0.01), and urine osmolality (U(osm)) was lower (1532 +/-71 versus 2056 +/- 83 mosM/kg H(2)O, mean +/-S.E., p < 0.001). After 24 h of water deprivation, U(osm) (in mosM/kg H(2)O) was 2403 +/- 38 in UT-B null mice and 3438 +/-98 in wild-type mice (p < 0.001). Plasma urea concentration (P(urea)) was 30% higher, and urine urea concentration (U(urea)) was 35% lower in knockout mice than in wild-type mice, resulting in a much lower U(urea)/P(urea) ratio (61 +/-5 versus 124 +/-9, p < 0.001). Thus, the capacity to concentrate urea in the urine is more severely impaired than the capacity to concentrate other solutes. Together with data showing a disproportionate reduction in the concentration of urea compared with salt in homogenized renal inner medullas of UT-B null mice, these data define a novel "urea-selective" urinary concentrating defect in UT-B null mice. The UT-B null mice generated for these studies should also be useful in establishing the role of facilitated urea transport in extrarenal organs expressing UT-B."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200207200"xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200207200"xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11792714 |
| http://purl.uniprot.org/citations/11792714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11792714 |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Verkman A.S."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Verkman A.S."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Epstein C.J."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Epstein C.J."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Gillespie A."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Gillespie A."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Bankir L."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/author | "Bankir L."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/pages | "10633-10637"xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/pages | "10633-10637"xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/title | "Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B."xsd:string |
| http://purl.uniprot.org/citations/11792714 | http://purl.uniprot.org/core/title | "Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B."xsd:string |