| http://purl.uniprot.org/citations/11796737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11796737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11796737 | http://www.w3.org/2000/01/rdf-schema#comment | "Remodeling of the extracellular matrix (ECM) is pivotal for various biological processes, including organ morphology and development. The Caenorhabditis elegans male tail has male-specific copulatory organs, the rays and the fan. Ray morphogenesis, which involves a rapid remodeling of the ECM, is an important model of morphogenesis, although its mechanism is poorly understood. ADAMTS (a disintegrin-like and metalloproteinase with thrombospondin type I motifs) is a novel metalloproteinase family that is thought to be an important regulator for ECM remodeling during development and pathological states. We report here that a new C. elegans ADAMTS family gene, adt-1, plays an important regulatory role in ray morphogenesis. Inactivation of the adt-1 gene resulted in morphological changes in the rays as well as the appearance of abnormal protuberances around the rays. In addition, mating ability was remarkably impaired in adt-1 deletion mutant males. Furthermore, we found that the green fluorescent protein reporter driven by the adt-1 promoter was specifically expressed throughout the rays in the male tail. We hypothesize that ADT-1 controls the ray extension process via remodeling of the ECM in the cuticle."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200144200"xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200144200"xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Asaka A."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Asaka A."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Baba C."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Baba C."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Hosono R."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Hosono R."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Kuno K."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Kuno K."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Matsushima C."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/author | "Matsushima C."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/pages | "12228-12236"xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/pages | "12228-12236"xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs."xsd:string |
| http://purl.uniprot.org/citations/11796737 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs."xsd:string |