| http://purl.uniprot.org/citations/11803548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11803548 | http://www.w3.org/2000/01/rdf-schema#comment | "Classical and atypical cadherins mediate calcium-dependent cell adhesion and play an important role in morphogenetic processes. We have shown, previously, N- and E-cadherin expression in the rat ovary. This expression, however, was not associated with specific follicle-restructuring events such as antrum formation and segregation of mural from cumulus granulosa cells suggesting that other cadherins may serve this function. In this study, RT-PCR and immunostaining techniques showed that three other cadherins are expressed throughout prepubertal ovarian development in the rat: one classical (P-) cadherin, and two atypical (K- and OB-) cadherins. RT-PCR analysis of isolated ovarian tissue compartments (granulosa cells and the residual ovarian tissue) agreed with the immunostaining results. Immunostaining showed P- and K-cadherin expression by granulosa, as well as thecal/interstitial cells, and also in oocytes of primordial follicles. P-cadherin expression was absent in oocytes of follicles in later stages of development compared to K-cadherin, which was found in oocytes at all stages of folliculogenesis. P-, K-, and OB-cadherin were expressed by the ovarian surface epithelial cells of neonatal animals but only P- and OB-cadherin expression were maintained in these cells in 25 day-old animals. Cellular OB-cadherin staining was absent in follicles at all stages of development and its expression was restricted to the ovarian hilar region and portions of the stroma. In summary, cadherin expression and distribution profiles changed during ovarian growth and folliculogenesis suggesting a role for cadherins in organizational and morphogenetic processes within the developing rat ovary."xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.org/dc/terms/identifier | "doi:10.1002/mrd.1141"xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/author | "Farookhi R."xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/author | "Blaschuk O.W."xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/author | "Machell N.H."xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/name | "Mol Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/pages | "142-154"xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/title | "Expression and localization of P-, K-, and OB-cadherin in the prepubertal rat ovary."xsd:string |
| http://purl.uniprot.org/citations/11803548 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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