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http://purl.uniprot.org/citations/11804584http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11804584http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11804584http://www.w3.org/2000/01/rdf-schema#comment"Pre-mRNA introns are spliced in a macromolecular machine, the spliceosome. For each round of splicing, the spliceosome assembles de novo in a series of ATP-dependent steps involving numerous changes in RNA-RNA and RNA-protein interactions. As currently understood, spliceosome assembly proceeds by addition of discrete U1, U2, and U4/U6*U5 snRNPs to a pre-mRNA substrate to form functional splicing complexes. We characterized a 45S yeast penta-snRNP which contains all five spliceosomal snRNAs and over 60 pre-mRNA splicing factors. The particle is functional in extracts and, when supplied with soluble factors, is capable of splicing pre-mRNA. We propose that the spliceosomal snRNPs associate prior to binding of a pre-mRNA substrate rather than with pre-mRNA via stepwise addition of discrete snRNPs."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(02)00436-7"xsd:string
http://purl.uniprot.org/citations/11804584http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(02)00436-7"xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Abelson J."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Abelson J."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Stevens S.W."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Stevens S.W."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Moore R.E."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Moore R.E."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Lee T.D."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Lee T.D."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Ge H.Y."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Ge H.Y."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Ryan D.E."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Ryan D.E."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Young M.K."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/author"Young M.K."xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/pages"31-44"xsd:string
http://purl.uniprot.org/citations/11804584http://purl.uniprot.org/core/pages"31-44"xsd:string