| http://purl.uniprot.org/citations/11805046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11805046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11805046 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial translation is largely membrane-associated in S. cerevisiae. Recently, we discovered that the matrix protein Nam1p binds the amino-terminal domain of yeast mtRNA polymerase to couple translation and/or RNA-processing events to transcription. To gain additional insight into these transcription-coupled processes, we performed a genetic screen for genes that suppress the petite phenotype of a point mutation in mtRNA polymerase (rpo41-R129D) when overexpressed. One suppressor identified in this screen was SLS1, which encodes a mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV. The mtRNA-processing defects associated with the rpo41-R129D mutation were corrected in the suppressed strain, linking Sls1p to a pathway that includes mtRNA polymerase and Nam1p. This was supported by the observation that SLS1 overexpression rescued the petite phenotype of a NAM1 null mutation. In contrast, overexpression of Nam1p did not rescue the petite phenotype of a SLS1 null mutation, indicating that Nam1p and Sls1p are not functionally redundant but rather exist in an ordered pathway. On the basis of these data, a model in which Nam1p coordinates the delivery of newly synthesized transcripts to the membrane, where Sls1p directs or regulates their subsequent handling by membrane-bound factors involved in translation, is proposed."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/160.1.75"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/160.1.75"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Shadel G.S."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Shadel G.S."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Bryan A.C."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Bryan A.C."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Rodeheffer M.S."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Rodeheffer M.S."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Wearn C.M."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/author | "Wearn C.M."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/pages | "75-82"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/pages | "75-82"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/title | "Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/title | "Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression."xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/11805046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11805046 |
| http://purl.uniprot.org/citations/11805046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11805046 |