| http://purl.uniprot.org/citations/11805143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11805143 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells and interferon (IFN)-gamma have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-gamma. In the absence of TRAIL, NK cells, or IFN-gamma, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20011171"xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Kayagaki N."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/author | "Cretney E."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/pages | "161-169"xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/title | "Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development."xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/11805143 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11805143 |
| http://purl.uniprot.org/citations/11805143 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11805143 |
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