| http://purl.uniprot.org/citations/11805328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11805328 | http://www.w3.org/2000/01/rdf-schema#comment | "Dsk2p from Saccharomyces cerevisiae belongs to the class of proteins that contain a ubiquitin-like (UbL) domain at the N terminus together with a ubiquitin-associated (UBA) domain at the C terminus. We show here that the C-terminal UBA domain of Dsk2p binds to K48-linked polyubiquitin chains, and the N-terminal UbL domain of Dsk2p interacts with the proteasome. Overexpression of Dsk2p caused the accumulation of large amounts of polyubiquitin, and extragenic suppressors of the Dsk2p-mediated lethality proved to be temperature-sensitive mutations in two proteasome subunits, rpn1 and pre2. K48-linked ubiquitin-dependent degradation was impaired by disruption of the DSK2 gene. These results indicate that Dsk2p is K48-linked polyubiquitin-binding protein and also interacts with the proteasome. We discuss a possible role of adaptor function of Dsk2p via its UbL and UBA domains in the ubiquitin-proteasome pathway."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.012585199"xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/author | "Kobayashi H."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/author | "Funakoshi M."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/author | "Nishimoto T."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/pages | "745-750"xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/title | "Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome."xsd:string |
| http://purl.uniprot.org/citations/11805328 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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