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| http://purl.uniprot.org/citations/11809706 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic myeloid leukemia is caused by the tyrosine kinase oncoprotein BCR/ABL. Using oligonucleotide arrays to assay mRNAs at different phases of the cell cycle in BCR/ABL-transformed cells, we found that cyclin D2 mRNA was constitutively expressed at high levels throughout the cell cycle, a pattern confirmed by immunoblotting of protein lysates. Bone marrow cells from cyclin D2-deficient strains of mice failed to proliferate in response to infection with a retrovirus carrying BCR/ABL and failed to generate transformed lymphoid cell lines in vitro. These results establish that BCR/ABL promotes cell cycle progression by altering expression of cyclin D2 and that cyclin D2 induction plays a critical role in proliferation of hematopoietic cells by BCR/ABL."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/author | "Daley G.Q."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/author | "Deng M."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/author | "Jena N."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/author | "Sicinska E."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/pages | "535-541"xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/title | "Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells."xsd:string |
| http://purl.uniprot.org/citations/11809706 | http://purl.uniprot.org/core/volume | "62"xsd:string |
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