| http://purl.uniprot.org/citations/11809832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11809832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11809832 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin-depolymerizing factor (ADF)/cofilins are essential regulators of actin filament turnover. Several ADF/cofilin isoforms are found in multicellular organisms, but their biological differences have remained unclear. Herein, we show that three ADF/cofilins exist in mouse and most likely in all other mammalian species. Northern blot and in situ hybridization analyses demonstrate that cofilin-1 is expressed in most cell types of embryos and adult mice. Cofilin-2 is expressed in muscle cells and ADF is restricted to epithelia and endothelia. Although the three mouse ADF/cofilins do not show actin isoform specificity, they all depolymerize platelet actin filaments more efficiently than muscle actin. Furthermore, these ADF/cofilins are biochemically different. The epithelial-specific ADF is the most efficient in turning over actin filaments and promotes a stronger pH-dependent actin filament disassembly than the two other isoforms. The muscle-specific cofilin-2 has a weaker actin filament depolymerization activity and displays a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1 and ADF. In steady-state assays, cofilin-2 also promotes filament assembly rather than disassembly. Taken together, these data suggest that the three biochemically distinct mammalian ADF/cofilin isoforms evolved to fulfill specific requirements for actin filament dynamics in different cell types."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.01-07-0331"xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.01-07-0331"xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Lappalainen P."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Lappalainen P."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Partanen J."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Partanen J."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Ojala P.J."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Ojala P.J."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Thesleff I."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Thesleff I."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Mustonen T."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Mustonen T."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Mattila P.K."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/author | "Mattila P.K."xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/pages | "183-194"xsd:string |
| http://purl.uniprot.org/citations/11809832 | http://purl.uniprot.org/core/pages | "183-194"xsd:string |