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http://purl.uniprot.org/citations/11812785http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11812785http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11812785http://www.w3.org/2000/01/rdf-schema#comment"DOC-2/DAB2 is a member of the disable gene family with tumor-inhibitory activity. Its down-regulation is associated with several neoplasms, and serine phosphorylation of its N terminus modulates DOC-2/DAB2's inhibitory effect on AP-1 transcriptional activity. We describe the cloning of DIP1/2, a novel gene that interacts with the N-terminal domain of DOC-2/DAB2. DIP1/2 is a novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminus) and two other unique domains (i.e. 10 proline repeats and leucine zipper). Interaction between DOC-2/DAB2 and DIP1/2 is detected in normal tissues such as the brain and prostate. Altered expression of these two proteins is often detected in prostate cancer cells. Indeed, the presence of DIP1/2 effectively blocks mitogen-induced gene expression and inhibits the growth of prostate cancer. Thus, DOC-2/DAB2 and DIP1/2 appear to represent a unique negative regulatory complex that maintains cell homeostasis."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m110568200"xsd:string
http://purl.uniprot.org/citations/11812785http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m110568200"xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Chen H."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Chen H."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"McConnell J.D."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"McConnell J.D."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Tseng C.-P."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Tseng C.-P."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Hsieh J.-T."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Hsieh J.-T."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Navone N."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Navone N."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Pong R.-C."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/author"Pong R.-C."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/pages"12622-12631"xsd:string
http://purl.uniprot.org/citations/11812785http://purl.uniprot.org/core/pages"12622-12631"xsd:string