| http://purl.uniprot.org/citations/11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11813884 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ca2+-dependent cell adhesion molecule E-cadherin has been known to express in normal and reactive Schwann cells in rodents, and to play an important role in Schwann cell-Schwann cell adhesion and maintenance of peripheral nervous tissue architecture. However, little is known about expression of E-cadherin in schwannomas. The aim of the present study was to investigate the cellular expression and localization of E-cadherin, and its associated protein, alpha E-, alpha N- and beta-catenins in human schwannomas, which are supposed to derive from Schwann cells. We tested the hypothesis that these proteins might show an altered expression/distribution in schwannoma cells which correlates with their neoplastic behavior, including sparse cell-cell contact, as seen those in meningiomas and various carcinomas. In human schwannomas, however, E-cadherin, alpha E-catenin, and beta-catenin were detected by western blotting and immunohistochemistry, whereas alpha N-catenin was not. Immunoprecipitation using anti-E-cadherin antibody resulted in alpha E-catenin forming a complex with E-cadherin. SSCP analysis revealed no mutations in the transmembrane domain or in intracellular catenin-binding site of E-cadherin. These data suggest that the E-cadherin-alpha E-catenin complex is well preserved in human schwannoma cells, which is compatible with its benign behavior, and these molecules might be used as additional cell markers of Schwann cell-derived tumors."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.org/dc/terms/identifier | "doi:10.14670/hh-17.39"xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Hasegawa M."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Yamashita J."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Fujisawa H."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Kida S."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Tohma Y."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Fukaya K."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Muramatsu N."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/author | "Tachibana O."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/name | "Histol Histopathol"xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/pages | "39-44"xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/title | "Expression of E-cadherin-catenin complex in human benign schwannomas."xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/11813884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11813884 |
| http://purl.uniprot.org/citations/11813884 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11813884 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11813884 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11813884 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11813884 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11813884 |
| http://purl.uniprot.org/uniprot/#_A0A6C0N5X1-mappedCitation-11813884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11813884 |