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| http://purl.uniprot.org/citations/11813981 | http://www.w3.org/2000/01/rdf-schema#comment | "CD21 serves as a receptor for the Epstein-Barr virus (EBV). In this report, surface expression of CD21 on B and T cells was shown to be suppressed by a thiol-antioxidant, N-acetylcysteine (NAC), in a dose- and time-dependent manner. In contrast, expression of other surface markers, CD25 and CD4 for T cells and CD19 and surface IgM for B cells, was not affected by NAC. When an EBV-negative B-cell line B104 was treated with NAC, the cells were not susceptible to infection with B95-8-derived EBV. The effect of NAC was shown to be irrelevant to the transcriptional levels of CD21 mRNA and the intracellular glutathione levels. Immunoprecipitation study revealed that NAC causes a loss of anti-CD21 monoclonal antibody (HB5) binding to both membrane and soluble CD21, suggesting that NAC modulates the structure of CD21. Other thiol-antioxidants, such as 2-mercaptoethanol, pyrrolidine dithiocarbamate, and glutathione, showed similar effect to NAC on CD21 expression. These results suggest the possible modulation of EBV infection via thiol-dependent redox control of CD21, and thiol-antioxidants may be good candidates for controlling EBV infection."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.org/dc/terms/identifier | "doi:10.1089/152308601317203585"xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/author | "Okada H."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/author | "Okada N."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/author | "Yodoi J."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/author | "Nishinaka Y."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/name | "Antioxid Redox Signal"xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/pages | "1075-1087"xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/title | "Redox control of EBV infection: prevention by thiol-dependent modulation of functional CD21/EBV receptor expression."xsd:string |
| http://purl.uniprot.org/citations/11813981 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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