| http://purl.uniprot.org/citations/11818334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11818334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11818334 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor suppressor Smad4 is the common signaling effector in the transforming growth factor beta (TGF-beta) superfamily. Phosphorylated regulatory Smads (R-Smads) interact with Smad4, and the complex translocates into the nucleus to regulate gene transcription. Proper TGF-beta signaling requires precise control of Smad functions. Smurfs have been shown to mediate the degradation of R-Smads but not the common-partner Smad4. We report a novel mechanism of Smad4 degradation. Jab1 interacts directly with Smad4 and induces its ubiquitylation for degradation. Jab1 was initially identified as a co-activator of c-Jun, and it also induces degradation of cell cycle inhibitor p27 and tumor suppressor p53. Ectopic expression of Jab1 decreased endogenous Smad4 steady-state levels. The 26S proteasome inhibitors lactacystin and MG132 reduced the degradation rate of Smad4 protein. Examination of the effects of JAB1-induced Smad4 degradation indicates that Jab1 inhibited TGF-beta-induced gene transcription. Our data suggest that Jab1 antagonizes TGF-beta function by inducing degradation of Smad4 through a distinct degradation pathway."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kvf024"xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kvf024"xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wan M."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wan M."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Bai S."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Bai S."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Cao X.'"xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/author | "Cao X.'"xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/11818334 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |