| http://purl.uniprot.org/citations/11822868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11822868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11822868 | http://www.w3.org/2000/01/rdf-schema#comment | "Normal cells display protective responses against oncogenes. Notably, oncogenic Ras triggers an irreversible proliferation arrest that is reminiscent of replicative senescence and that is considered a relevant tumor-suppressor mechanism. Here, we have used microarrayed filters to identify genes specifically upregulated in Ras-senescent human fibroblasts. Among the initial set of genes selected from the microarrays, we found the cell-cycle inhibitor p21(Cip1/Waf1), thus validating the potency of the screening to identify markers and mediators of Ras-senescence. A group of six genes, formed by those more highly upregulated during Ras-senescence, was analyzed in further detail to evaluate their specificity. In particular, we examined their expression in cells overexpressing Ras but rendered resistant to Ras-senescence by the viral oncoprotein E1a; also, we have studied their expression during replicative senescence, organismal aging, H(2)O(2)-induced senescence, and DNA damage. In this manner, we have identified a novel gene, RIS1 (for Ras-induced senescence 1), which is not upregulated in association to any of the above-mentioned processes, but exclusively during Ras-senescence. Furthermore, RIS1 is also upregulated by the transcriptional factor Ets2, which is a known mediator of Ras-induced senescence. Interestingly, RIS1 is located at chromosomal position 3p21.3 and, more specifically, it is included in a short segment of just 1 Mb previously defined by other investigators for its tumor-suppressor activity. In summary, we report the identification of a novel gene, RIS1, as a highly specific marker of Ras-induced senescence and a candidate tumor-suppressor gene."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.2001.5434"xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.2001.5434"xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Serrano M."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Serrano M."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Delgado M.D."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Delgado M.D."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Hara E."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Hara E."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Gonos E.S."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Gonos E.S."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Petropoulou C."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Petropoulou C."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Barradas M."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Barradas M."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Kolettas E."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Kolettas E."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Zebedee Z."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/author | "Zebedee Z."xsd:string |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11822868 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |